Interferon and Interferon-Induced Chemokine Expression Is Associated with Control of Acute Viremia in West Nile Virus-Infected Blood Donors
Identifieur interne : 003206 ( Main/Exploration ); précédent : 003205; suivant : 003207Interferon and Interferon-Induced Chemokine Expression Is Associated with Control of Acute Viremia in West Nile Virus-Infected Blood Donors
Auteurs : Leslie H. Tobler [États-Unis] ; Mark J. Cameron [Canada] ; Marion C. Lanteri [États-Unis] ; Harry E. Prince [États-Unis] ; Ali Danesh [États-Unis] ; Desmond Persad [États-Unis] ; Robert S. Lanciotti [États-Unis] ; Philip J. Norris [États-Unis] ; David J. Kelvin [États-Unis] ; Michael P. Busch [États-Unis]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2008.
Abstract
To understand early host responses controlling West Nile virus (WNV) infection, acutely viremic blood donors, identified by nucleic acid amplification testing, were enrolled and monitored for RNA-clearance and WNV-specific IgM and IgG antibodies. Viral load and chemokine and cytokine assays were performed on serial samples from donors whose index and first follow-up samples tested negative for IgM. A total of 84% of the specimens obtained from viremic donors before IgM/IgG seroconversion demonstrated a decreasing viral load. Levels of interferon (IFN)-α ere significantly increased before IgM seroconversion, relative to those in control specimens. CXCL10 and CCL2 were significantly elevated in donor specimens obtained before IgM seroconversion, compared with those obtained after IgM seroconversion. These findings suggest that IFN-mediated innate immunity plays a key role in initial control of WNV replication.
Url:
DOI: 10.1086/591466
Affiliations:
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</title><author><name sortKey="Tobler, Leslie H" sort="Tobler, Leslie H" uniqKey="Tobler L" first="Leslie H." last="Tobler">Leslie H. Tobler</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Blood Systems Research Institute</wicri:orgArea></affiliation><affiliation></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Reprints or correspondence: Dr. Leslie H. Tobler, Blood Systems Research Institute, 270 Masonic Ave., San Francisco</wicri:cityArea></affiliation></author><author><name sortKey="Cameron, Mark J" sort="Cameron, Mark J" uniqKey="Cameron M" first="Mark J." last="Cameron">Mark J. Cameron</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>University of Health Network, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Lanteri, Marion C" sort="Lanteri, Marion C" uniqKey="Lanteri M" first="Marion C." last="Lanteri">Marion C. Lanteri</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Blood Systems Research Institute</wicri:orgArea></affiliation></author><author><name sortKey="Prince, Harry E" sort="Prince, Harry E" uniqKey="Prince H" first="Harry E." last="Prince">Harry E. Prince</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Focus Diagnostics, Cypress</wicri:cityArea></affiliation></author><author><name sortKey="Danesh, Ali" sort="Danesh, Ali" uniqKey="Danesh A" first="Ali" last="Danesh">Ali Danesh</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Focus Diagnostics, Cypress</wicri:cityArea></affiliation></author><author><name sortKey="Persad, Desmond" sort="Persad, Desmond" uniqKey="Persad D" first="Desmond" last="Persad">Desmond Persad</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Focus Diagnostics, Cypress</wicri:cityArea></affiliation></author><author><name sortKey="Lanciotti, Robert S" sort="Lanciotti, Robert S" uniqKey="Lanciotti R" first="Robert S." last="Lanciotti">Robert S. 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Busch</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Blood Systems Research Institute</wicri:orgArea></affiliation><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName><wicri:orgArea>Department of Laboratory Medicine, University of California</wicri:orgArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2008</date><biblScope unit="vol">198</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="979">979</biblScope><biblScope unit="page" to="983">983</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">To understand early host responses controlling West Nile virus (WNV) infection, acutely viremic blood donors, identified by nucleic acid amplification testing, were enrolled and monitored for RNA-clearance and WNV-specific IgM and IgG antibodies. Viral load and chemokine and cytokine assays were performed on serial samples from donors whose index and first follow-up samples tested negative for IgM. A total of 84% of the specimens obtained from viremic donors before IgM/IgG seroconversion demonstrated a decreasing viral load. Levels of interferon (IFN)-α ere significantly increased before IgM seroconversion, relative to those in control specimens. CXCL10 and CCL2 were significantly elevated in donor specimens obtained before IgM seroconversion, compared with those obtained after IgM seroconversion. These findings suggest that IFN-mediated innate immunity plays a key role in initial control of WNV replication.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Californie</li><li>Colorado</li></region><settlement><li>San Francisco</li></settlement></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Tobler, Leslie H" sort="Tobler, Leslie H" uniqKey="Tobler L" first="Leslie H." last="Tobler">Leslie H. Tobler</name></region><name sortKey="Busch, Michael P" sort="Busch, Michael P" uniqKey="Busch M" first="Michael P." last="Busch">Michael P. Busch</name><name sortKey="Busch, Michael P" sort="Busch, Michael P" uniqKey="Busch M" first="Michael P." last="Busch">Michael P. Busch</name><name sortKey="Danesh, Ali" sort="Danesh, Ali" uniqKey="Danesh A" first="Ali" last="Danesh">Ali Danesh</name><name sortKey="Kelvin, David J" sort="Kelvin, David J" uniqKey="Kelvin D" first="David J." last="Kelvin">David J. Kelvin</name><name sortKey="Lanciotti, Robert S" sort="Lanciotti, Robert S" uniqKey="Lanciotti R" first="Robert S." last="Lanciotti">Robert S. Lanciotti</name><name sortKey="Lanteri, Marion C" sort="Lanteri, Marion C" uniqKey="Lanteri M" first="Marion C." last="Lanteri">Marion C. Lanteri</name><name sortKey="Norris, Philip J" sort="Norris, Philip J" uniqKey="Norris P" first="Philip J." last="Norris">Philip J. Norris</name><name sortKey="Norris, Philip J" sort="Norris, Philip J" uniqKey="Norris P" first="Philip J." last="Norris">Philip J. Norris</name><name sortKey="Persad, Desmond" sort="Persad, Desmond" uniqKey="Persad D" first="Desmond" last="Persad">Desmond Persad</name><name sortKey="Prince, Harry E" sort="Prince, Harry E" uniqKey="Prince H" first="Harry E." last="Prince">Harry E. Prince</name><name sortKey="Tobler, Leslie H" sort="Tobler, Leslie H" uniqKey="Tobler L" first="Leslie H." last="Tobler">Leslie H. Tobler</name></country><country name="Canada"><noRegion><name sortKey="Cameron, Mark J" sort="Cameron, Mark J" uniqKey="Cameron M" first="Mark J." last="Cameron">Mark J. Cameron</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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